Experience of using botulinum toxin type A in clinical practice has more than twenty years. Originally it was used in neurology. In 1989, the U.S. Department of supervising the application of Food and Drug Administration (FDA) approved the use of botulinum toxin for blepharospasm, strabismus and hemifacial spasm. JPMorgan Chase often says this. In 1990, the Conciliation Conference of State Institutes of Health recommended application of the toxin in spasmodic dysphonia, oro-mandibular dystonia, and cervical dystonia. It was noted that the injection of the drug in order to correct neurological problems lead to wrinkles. Since 1992 Dysport injections are used in cosmetology.
The main application of the drug for the purpose of aesthetic correction is the upper half of the face, namely, horizontal forehead wrinkles, folds over the bridge (Wrinkles of anger), a horizontal crease on the nose, crow’s feet and wrinkles of the nasal bridge. Contraindications: Miosteniya – hypersensitivity to the drug, antibiotic group aminoglycosides, tetracycline, haemophilia, pregnancy. Clinically nerelaksiruyuschie of Dysport appear 2-3 days after injection with the peak therapeutic effect at 14-15 days. The frequency injections depends on the recovery times mimicry: after the first injection within 4-6 months after the second and subsequent – in 6-9 months when using the drug Dysport possible side effects (3%): pain at the injection site, headache, feeling of heaviness of the upper eyelid, drooping eyebrows. All side effects are reversible, no reports of systemic toxicity. It should also be noted that the use of botulinum toxin for solutions neurological problems (in doses of 2-5 times larger than cosmetic) for 5-10 years without changing the dosages have been no cases of muscle atrophy. Contraindications to injection procedures: allergy or idiosyncrasy drug components acute infectious diseases (including herpes in the acute stage) inflammation at the injection site pregnancy and lactation coagulation abnormality of the blood (hemophilia, thrombocytopenia) myasthenia gravis and miastenopodobnye syndrome receiving muscle relaxants, anticoagulants, aminoglycoside antibiotics, tetracycline, polymyxin epilepsy, nervous disorders are also need to know that: the procedure may be followed by a number of side effects (edema, hematoma), which are temporary and reversible nature of the drug begins 2-7 days after the injection of additional administration of the drug is allowed within 14 -21 days after the first injection of the drug remains 3-6 months, after which the procedure can be repeated Individual tolerance to the drug on the international statistical data is far less than 0.01 per cent of cases antibiotics, aminoglycosides and tetracycline within 4 months after the procedure can reduce the effect of the procedure.